In lieu of an abstract, here is a brief excerpt of the content:176 HUME ON PROMISES AND THEIR OBLIGATION This discussion of Hume's account of promises pursues certain issues raised by William Vitek in his paper "The Humean Promise: Whence Comes Its Obligation?" The question I consider first is what, for Hume, it is for someone to make a promise. I then go on to consider Hume's view of promisekeeping as an artificial virtue and the distinction which Hume makes between (...) two kinds of obligation in relation to promises: a natural and an artificial obligation. The issue with which I am principally concerned is how far Hume succeeds in explaining our recognition of the obligation to keep promises. The Humean Promise There is implicit in Hume's "Of the Obligation of Promises" an account of what it is for someone to make a promise, i.e., of the conditions which are at least necessary for this to occur. It is worthwhile making these conditions explicit in order to bring out points of similarity with the celebrated account of promises provided in recent 4 philosophy by John Searle. We find in both Hume and Searle a recognition that promising is a social institution which depends upon certain conventions, and that the conditions for promising reflect these conventions. Among the conditions which appear to be common to their different accounts are the following: 1.That a certain form of words is used (typically, of the form ' I promise...'). 2.That these words are understood by the speaker. 177 3.That they predicate an act of the speaker which will be performed for the interest or advantage of another. 4.That the action is not one which the speaker would undertake in the normal course of events. 5.That the speaker's utterance expresses a serious intention or resolution. 6.That in making this utterance the speaker wills the obligation to act accordingly. Let me comment briefly on these conditions. 1.The condition that a certain form of words is used in effect acknowledges that promising involves a distinctive type of speech act: namely, one which can, in itself, bind the speaker to the performance of an action (T 522). Presumably, however, this does not necessarily require the actual use of the words · I promise' — the context may determine that a promise has been made, even without the use of these words. We should note that language itself is, for Hume, the product of a convention (T 490); so also, therefore, must be the institution of promisemaking and promise-keeping. 2.The condition that these words are understood by the speaker is implicit in Hume's comment that while "the expression makes on most occasions the whole of the promise," someone who makes use of the expression without understanding its meaning "wou'd not certainly be bound by it" (T 523). It is a condition which relates to what Searle describes as the normal 'input' and 'output' conditions, i.e., the conditions which govern "serious and literal linguistic communication." It is presupposed, for example, that the speaker (and perhaps also the hearer) knows how to speak 178 the language, that he is not play-acting or speaking in jest, and so on. 3.The condition that these words predicate an act of the speaker for the interest or advantage of another is obviously implicit, at least, in Hume's account of promise-keeping as an artificial virtue (of which I will say more later). But it should be emphasised that a promise is not simply an undertaking to act in a certain way towards another person: it is a matter of undertaking to do something for that person. 4.That the action is not one which the speaker would normally undertake, again, is a condition for which Hume caters: indeed, it is an essential part of his account that an action which a person promises to perform is not one which would occur in accordance with his natural passions or inclinations (T 519). There may, nevertheless, be possible exceptions to this, as where someone promises to do something which self-interest would incline him to do anyway. But in this kind of case promising has for Hume the special function of increasing the... (shrink)

The integrated stress response (ISR) is a key determinant of tumorigenesis in response to oncogenic forms of stress like genotoxic, proteotoxic and metabolic stress. ISR relies on the phosphorylation of the translation initiation factor eIF2 to promote the translational and transcriptional reprogramming of gene expression in stressed cells. While ISR promotes tumor survival under stress, its hyperactivation above a level of tolerance can also cause tumor death. The tumorigenic function of ISR has been recently demonstrated for lung adenocarcinomas (LUAD) with (...) KRAS mutations. ISR mediates the translational repression of the dual‐specificity phosphatase DUSP6 to stimulate ERK activity and LUAD growth. The significance of this finding is highlighted by the strong anti‐tumor responses of ISR inhibitors in pre‐clinical LUAD models. Elucidation of the mechanisms of ISR action in LUAD progression via cell‐autonomous and immune regulatory mechanisms will provide a better understanding of its tumorigenic role to fully exploit its therapeutic potential in the treatment of a deadly form of cancer. (shrink)

This is a clear assessment of Hume's theories of the self and personal identity, including his famous Treatise on Human Nature . Pitson provides a critical exploration of his thinking, also examining the continuing relevance of Hume's theories for contemporary philosophy and relating it to his broader reflections on human nature itself. Divided into two parts, Pitson's study follows Hume's important distinction between two aspects of personal identity: the "mental" and the "agency". The first part discusses Hume's conception (...) of the mind as a "bundle" or "system" of perceptions and explores Hume's position on the traditional mind/body problem. In the second part Pitson examines a range of topics including Hume's treatment of character, the relationship between human and animal nature, and the nature of agency. (shrink)

Hume’s remark that “the conviction of religionists, in all ages, is more affected than real” is considered in relation to various monotheistic beliefs against the background of his account of belief more generally. The issue arises as to what Hume means by characterizing the assent associated with religious belief as an operation between disbelief and conviction. According to Hume, the obscurity of the ideas involved in the religious convictions of the “vulgar” prevents them from achieving the force and vivacity characteristic (...) of belief. As for philosophers, their idea of God encounters the problem of evil and the question of whether it is possible for the deity to possess moral virtues. Even the ascription to God of natural attributes takes us beyond what may meaningfully be imagined. Finally, the philosophical idea of God as a principle of order provides a form of theistic belief that is only verbally different from atheism. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:61 PROJECTIONISM, REALISM, AND HUME'S MORAL SENSE THEORY* Introduction The character of Hume's moral theory is currently a topic of considerable discussion.1 We find in the recent literature essentially two sorts of interpretation of Hume's theory. On the one side there is the view that, for Hume, the distinction between virtue and vice is reducible to the moral sentiments of approval and disapproval. Associated with this view is the (...) further claim that Hume ascribes to us the belief that virtue and vice exist as the counterparts to these sentiments; and, in addition, that this belief is, for Hume, a mistaken one. For reasons which will become obvious this may be described as the Projectionist account of Hume. On the other side, there is the attempt to represent Hume's moral theory as a form of realism, i.e., a theory according to which there are moral properties belonging to actions, or the agents who perform them, which provide objective correlates of the feelings which those actions, or the agents concerned, induce in us as spectators. Now clearly an important part of what is at stake between these different interpretations is the question of how seriously we should take Hume's own description of this theory as one according to which moral distinctions are derived from a moral sense. It is characteristic of the Projectionist interpretation to suggest that 'sense' is equivalent here to 'sentiment', and, indeed, that Hume's moral sense theory is tantamount to the denial that there is anything in Objects' themselves corresponding to our moral (or aesthetic) sentiments. The Realist interpretation, on the other hand, stresses the importance of Hume's references in 62 the Treatise to a moral (and aesthetic) sense, and the precedent provided in this respect by Hutcheson; and it takes seriously the idea that this sense enables us to become acquainted, via the sentiments involved, with the qualities of virtue and vice. My own interest in these different interpretations concerns their disagreement about the way in which we should understand Hume's notion of a moral sense. I wish to argue against the Projectionist interpretation, and its dismissive treatment of Hume's references to a moral sense, though it is a further question whether the view of Hume which emerges deserves the name of 'Realism'. 1. The Projectionist Interpretation It seems clear that the notion of a moral sense cannot be intended literally, i.e., as though there is a form of moral sense-perception strictly comparable to the modes of perception provided by the external senses. It is, presumably, part of the definition of a sense that it is a faculty whose function depends upon stimulation of an organ or, at least, receptors peculiar to that sense; and, furthermore, in the case of the various external senses there is -- except for the contact sense of touch -- a distinctive medium of perception. For both these reasons moral sense theorists can only be proposing an analogy with the external senses. In Hume's case in particular, however, there appear to be reasons for doubting whether the analogy can be more than superficial. Perhaps the most obvious of these lies with Hume's insistence on the action-guiding character of the distinction between moral good and evil (see e.g., T 437-462). For it seems clear that sense-perceptions g as such can have no direct influence upon our actions. 63 Then there is Hume's denial that morality consists in any matter of fact (T 468; EPM 292). If virtue and vice are to be considered the objects of some form of moral sense-perception their existence presumably does become a matter of fact. Finally, a moral sense theory seems to imply that judgements of virtue and vice are straightforwardly true or false, according to whether or not we perceive veridical Iy; while Hume's own discussion sometimes points to a non-propositional view of moral utterances as the expression of certain feelings or sentiments. These last two points remind us that Hume often appears to deny that values belong as intrinsic properties to the objects evaluated. This is obviously true of the following, much quoted, passage: Take any... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:125. HUME ON PRIMARY AND SECONDARY QUALITIES Hume's view of the primary/secondary quality distinction is, I believe, a matter of considerable interest. It bears upon Hume's position in relation to Locke and Berkeley, and has important implications for general features of his epistemology and metaphysics. The central part of my discussion will therefore be taken up with a consideration of those passages from his writings in which Hume refers (...) to the primary/ secondary quality distinction. Hume's treatment of this aspect of the 'modern philosophy' may be seen against the background of his discussion of perception and its objects, and it is therefore this with which I begin. HUME'S SYSTEM I refer to Hume's system in relation to perception and the manner in which objects affect the senses. Hume's avowed purpose here is to discuss the way in which objects appear to the senses (in particular, those of sight and touch), rather than to account for their real nature and operations. Our ignorance of the nature of bodies reflects the fact that we are limited in experience to those properties of objects which discover themselves 2 to the senses. In determining the nature of Hume's system there are, I think, two (related) factors to be taken into account: (i) Hume's distinction between perceptions and objects; and (ii) Hume's critique of the Naive or Direct Realist theory of perception. (i) Perceptions and Objects The distinction which Hume wishes to make between perceptions and objects, and his general account of the relation between them, is embodied in his 126. discussion of the idea of external existence (T 6). We may observe, that 'tis universally allow'd by philosophers, and is besides pretty obvious of itself, that nothing is ever really present with the mind but its perceptions or impressions and· ideas, and that external objects become known to us only by the perceptions they 3 occasion. We should note that what Hume is describing here is, in essence, the Indirect Realist account of perception, i.e. that we are acquainted with an external reality only in the form of perceptions ('impressions') which arise from sensory contact with it. That Hume is prepared to speak elsewhere of per4 ceptions in their relation to external objects as images is indicative of his commitment to a Representative theory. There are, of course, severe limitations upon our understanding of the relation between perceptions and objects. As every idea is deriv'd from a preceding perception, 'tis impossible our idea of a perception, and that of an object or external existence can ever represent what are specifically different from each other. In so far as external objects are supposed to differ from perceptions in their specific identity, we can form only a relative idea of them (T 68). Nevertheless the idea of bodies or objects is clearly to be distinguished from that of perceptions; while being specifically the same, like ideas and impressions, these items, or rather the ideas involved, are attended with the supposition of a difference, that is unknown and incomprehensible (T 244). As different existences perceptions and objects may be conceived to differ in respect of their relational properties, for example, but otherwise whatever is true of the one must also be true of the other. These two sets of distinctions — between, on the one hand, ideas and impressions and, on the other, perceptions and objects — may usefully be compared and 127. contrasted. In each case the items with which we are concerned are numerically different but specifically identical; and, furthermore, the relation between the items which make up each pair is a causal one. The obvious difference between the two cases is that while both impressions and ideas are objects of experience, the causal dependence of the one upon the other being revealed by the order of their appearance before the mind, we do not directly experience external objects as opposed to perceptions. Questions concerning the 'real nature' of objects or bodies belong to the province of natural - rather than 'moral' - philosophy, which indeed has reasonable hypotheses to offer (T 48). As for our idea of body, this comprises nothing more than the ideas... (shrink)

Tenth annual conference at the University of Manchester, 8th-10th April 1983.

The second word in the subtitle of this article is crucial. For there can be no doubt but that the possibility of sociobiology below the human level has already been abundantly realized in, for instance, the main body of E. O. Wilson's enormous and encyclopedic treatise Sociobiology: The New Synthesis. What may more reasonably be doubted, and what is in fact questioned here, is whether, as Wilson and others hope and believe, there is much room, or indeed any, for a (...) sociobiology of our own notoriously wayward and idiosyncratic species. In proposing this particular project Wilson and his colleagues have seen themselves as promoting a climactic conquest for evolutionary biology. For surely, they seem to have thought, now, more than a century after Darwin, it is high time and past time to launch the final assault upon the last citadel. But, as we shall proceed to argue, there are reasons—reasons which were available at least in outline even to Darwin himself—why the ideas which have been so triumphantly successful in explaining The Origin of Species cannot properly be applied to what is in truth a fundamentally different task. They cannot, that is to say, properly be transferred to explain developments either within or out of the particular problem species of which the author of that book, along with both all the authors and all the readers of all other books, have been themselves members. (shrink)

One of the most commonly referenced ethical principles when it comes to the management of dying patients is the doctrine of double effect (DDE). The DDE affirms that it is acceptable to cause side effects (e.g. respiratory depression) as a consequence of symptom‐focused treatment. Much discussion of the ethics of end of life care focuses on the question of whether actions (or omissions) would hasten (or cause) death, and whether that is permissible. However, there is a separate question about the (...) permissibility of hastening or causing unconsciousness in dying patients. Some authors have argued that the DDE would not permit end of life care that directly aims to render the patient unconscious. The claim is that consciousness is an objective human good and therefore doctors should not intentionally (and permanently) suppress it. Three types of end of life care (EOLC) practices will be explored in this article. The first is symptom‐based management (e.g. analgesia); the second is proportional terminal sedation as a means of relieving suffering (also referred to as palliative sedation or continuous deep sedation); and finally, deliberate and rapid sedation to unconsciousness until death (a practice we call terminal anaesthesia in this paper). After examining the common arguments for the various types of symptom‐based management and sedation, we apply the DDE to the latter two types of EOLC practices. We argue that aiming at unconsciousness, contrary to some claims, can be morally good or at least morally neutral in some dying patients. (shrink)

Le statut de Pierre Bayle dans l'histoire des idées philosophiques et religieuses de l'époque classique a changé du tout au tout. D'observateur, il est devenu, dans l'historiographie actuelle, un acteur majeur dans les débats philosophiques, religieux et politiques de son époque, dont les écrits nourriront la réflexion des philosophes clandestins qui fondent les Lumières radicales. Ce volume d'études contribue à cette nouvelle interprétation du statut et de la portée du rationalisme de Bayle.

In lieu of an abstract, here is a brief excerpt of the content:Isaac Barrow on the Mathematization of Nature: Theological Voluntarism and the Rise of Geometrical OpticsAntoni MaletIntroductionIsaac Newton’s Mathematical Principles of Natural Philosophy embodies a strong program of mathematization that departs both from the mechanical philosophy of Cartesian inspiration and from Boyle’s experimental philosophy. The roots of Newton’s mathematization of nature, this paper aims to demonstrate, are to be found in Isaac Barrow’s (1630–77) philosophy of the mathematical sciences.Barrow’s attitude (...) towards natural philosophy evolved from his earnest interest in medicine of around 1650, when a young Cambridge graduate, to natural philosophy (apparently under Henry More’s influence); from his thesis on the insufficiency of the Cartesian hypothesis to geometrical optics and the strong program of mathematization of natural philosophy of the middle 1660s; from Lucasian professor of Mathematics to Chaplain of his Majesty and eminent Restoration divine. Contemporary accounts of Barrow’s life suggest that he grew ever more skeptical about the worth of natural philosophy and mathematics. 1 In his last years he became a prolific [End Page 265] author of sermons and theological works. Published shortly after his death by John Tillotson (1630–94), later archbishop of Canterbury, they occupy over two thousand folio pages. Overloaded with involved philosophical arguments, Barrow’s sermons were apparently not very popular, but they were highly regarded by scholars and the Anglican hierarchy. 2 It is on certain of his sermons, as well as on the philosophical discussions contained in the Mathematical Lectures that our account of Barrow’s philosophy of the mathematical sciences will rest. 3 Barrow’s understanding of the mathematical sciences will allow us to discuss together three issues often analyzed independently: the theological background to English natural philosophy, the changing notion of mixed mathematical sciences during the seventeenth century, and finally the philosophical foundations of modern geometrical optics.It has long been recognized that significant relationships exist between theological voluntarism or intellectualism and views on natural philosophy. In particular Robert Boyle’s theological voluntarism is seen as grounding his experimentalist approach to natural philosophy. It is not quite so clear, however, how well theological voluntarism may relate to a strong program of mathematization such as the one embodied in Newton’s Principia Mathematica. In fact it has been suggested that the relationship is a negative one. This is derived from the necessary character of mathematical laws, which would put unwanted restrictions on God’s absolute dominion over nature, and also from the notion that theological intellectualism is conducive to a deductive, a priori science—the paradigm of which is of course geometry. However, Barrow’s theological voluntarism lead him to heighten the role of mathematics within natural philosophy.During the seventeenth century the so-called mixed or subalternate mathematical sciences changed profoundly. In the Enlightenment mixed mathematics—meaning above all rational mechanics—became one of the most prestigious and influential disciplines. The mixed mathematics of the Enlightenment, however, was markedly different from the Aristotelian [End Page 266] mixed mathematical sciences. The differences are noticeable both in the subject matter and in the substitution of mathematical infinitesimal analysis for geometrical synthesis, but also in the way of grounding mathematical theory on empirical evidence. Barrow’s Mathematical Lectures (delivered at Cambridge from 1664 to 1666) offer a fresh insight into the metamorphosis of these sciences just when Newton’s “mathematical principles” were in the making. Not the least interesting feature of Barrow’s discussion is that God’s omnipotence allows an evaluation of the truth of mathematical theories that do not apply to this world. Therefore, Barrow is led to introduce the distinction between the internal consistency, or mathematical truth, of a mathematical theory and its physical truth. This, in turn, leads him to the notion that theories need testing.Barrow on Matter and GodRecent literature has established significant correlations between theological voluntarism and empiricism, as well as between theological intellectualism and rationalism. As E. B. Davis writes, “the Christian doctrine of creation is a dialogue between God’s unconstrained will, which utterly transcends the bounds of human comprehension, and God’s orderly intellect, which serves as the model for the human mind.” Intellectualist theology considers God’s omniscience His... (shrink)

This paper reinvents Freire’s concepts of ‘banking education’ and ‘literacy’ within the context of the exponential growth of digital instruction in the 21st century. We argue that digital learning (i.e. online or technology enhanced) undoubtedly increases access to education globally, but also can intensify some of the worst problems described in Freire’s banking model. Accordingly, we draw from postdigital theory to scrutinize the specific structures and functions of common digital Learning Management Systems (LMSs) used by schools (i.e. Blackboard and Google (...) Classroom) to reveal a type of learning that further exacerbates the teacher-student dichotomy without liberating either party in a Freirean sense. We then use a Foucauldian lens to bring an awareness to how the accelerated use of these systems at scale, in part caused by the COVID-19 pandemic, can further entrench a data-driven, dehumanized educational experience which increases corporate profitability perhaps over the needs of students. Finally, we use these insights to modernize Freire’s concept of ‘literacy’ by building on Critical Medial Literacy (CML) in order to help educators address LMSs, (mis)information facilitated by digital content, and schooling in a (post)pandemic and postdigital world. (shrink)

The anonimous scholiumOn all forms of syllogism was copied in 1884 from the Paris Codex 2064 by E. Richter. In 1899 M. Wallies published it in the preface to Ammonius' commentary on the Prior Analytics of Aristotle. There appear in that scholium, apart from the complex figure of Galenos, other characteristic forms of inference.Among these forms I found five so-called non-demonstrable stoic syllogisms, three modifications of the law of transposition of which the third is not mentioned by the authors of (...) Princ pia Mathematica, and a modification of the form of inference known as Euclid's law. This form of inference was applied by Euclid in mathematics and by Saccherius in syllogistics; it is mentioned for the first time by Cardan in a treatise of 1570 and later by Clavius in his commentary of 1574 on the Elements of Euclid and in the commentary on Theodosius'Sphaerica of the year 1586.In 1658 Erhard Weigel made the first attempt at refuting the logical law of Euclid as formulated by Cardan and Clavius and in 1686 James Bernoulli tried to prove it. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Commentary on “Psychopathy, Other-Regarding Moral Beliefs, and Responsibility”R. A. Duff (bio)AbstractI make four criticisms of Fields’s account of one type of psychopathy as a responsibility-negating personality disorder which involves an incapacity to form other-regarding moral beliefs. First, his account of what it is to hold moral beliefs (in terms of accepting universal practical principles) actually specifies neither a necessary, nor a sufficient, condition for holding a moral belief. Second, (...) he is too quick to dismiss the suggestion that what psychopaths suffer from is an inability to understand moral concepts and values. Third, he does not show why we should ascribe an incapacity to accept moral beliefs to the psychopath, rather than a culpable failure to do so. Fourth, he suggests too weak a criterion of criminal liability, as requiring only the capacity to act for prudential reasons.KeywordsMoral beliefs, moral understanding, incapacity, criminal liabilityFields argues that we can properly count at least one type of psychopathy as a personality disorder which negates moral responsibility. This is not because, as others have argued, such psychopaths cannot understand moral concepts and moral values, but because they suffer an incapacity to form other-regarding moral beliefs, i. e., to accept practical moral principles; we cannot hold them morally responsible for failing to accept or obey moral principles which they lack the capacity to accept. Nor, he also argues, should we hold them criminally liable, since they lack that capacity to act for prudential reasons to which a deterrent system of law appeals.His paper rightly emphasizes the interdependence of psychiatry and philosophy, in this as in other contexts. A psychiatric account of psychopathy as a disorder involving some kind of moral incapacity must depend for its precise sense on an adequate account of the concepts of moral capacity and incapacity: an account which should draw on the resources of moral philosophy. Philosophers who aim to understand those concepts will do well to attend, as Fields does attend, to psychiatric discussions and case histories: not only because this is necessary if their comments on mental disorder or on psychopathy are to be adequately informed, but also because careful attention to the problematic phenomena of mental disorder can also illuminate our understanding of the rational powers and capacities which are lacking or distorted in the disordered, and which philosophers hope to analyze. Fields is also clearly right to emphasize that the criteria of moral responsibility might not be the same as the appropriate [End Page 283] criteria of criminal liability: that the question of whether psychopaths should be criminally liable cannot necessarily be answered simply by determining whether they are morally responsible.However, I do not think that he has provided an adequate account of psychopathy as a personality disorder which negates moral responsibility and criminal liability. I will comment on four aspects of his discussion.First, as Fields recognizes, one who wants to argue that psychopaths lack the capacity to form moral beliefs owes us an account of what it is to form, or hold, a moral belief. Fields’s account is familiar, but arguable. To hold a moral belief is to accept, and to be motivated by, a universal practical principle: a principle which one regards as providing very strong reasons for action, and breaches of which arouse such responses as (third-person) disapproval or (first-person) guilt. It could be plausibly objected, however, that accepting some universal practical principle is neither a necessary nor a sufficient condition for holding a moral belief.It is not a sufficient condition, partly because not any universal practical principle which an agent treats as being important can intelligibly count as a moral principle. The principle “One should never split an infinitive” cannot, by itself, count as a moral principle; and if someone treated it as if it were a moral principle, we would judge his moral understanding, and his rational capacities, to be seriously impaired. This suggests that a purely formal account of the “moral,” like Fields’s (an account that pays no attention to the content of what could count as a moral principle) cannot be adequate (see Foot 1978). A further, related reason for the... (shrink)

Expressions designating collectives, such as “the committee” or “the ships in the port”, may be interpreted de re or de dicto, depending on context, according as they pick out collectives defined by their members or collectives defined by some criterion for membership. We call these E-collectives and I-collectives respectively, and in this paper we explore in depth the relationship between these two categories. In particular, we identify important respects in which they differ, regarding the nature of the dependence of the (...) collective on its members, the nature of the parthood relation in which the members stand to the whole, and, from an application perspective, the different methods used for identifying the two forms of collective from large spatio-temporal data-sets. (shrink)